TONSL Antibody, HRP conjugated

Datasheet

Code	CSB-PA836224LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TONSL Polyclonal antibody

Uniprot No.

Q96HA7

Target Names

TONSL

Alternative Names

I kappa B related protein antibody; I-kappa-B-related protein antibody; IkappaBR antibody; IKBR antibody; Inhibitor of kappa B related protein antibody; Inhibitor of kappa B-related protein antibody; MMS22L-interacting protein antibody; MMS22L-interacting protein, NFBIL2/TONSL antibody; NF kappa B inhibitor like protein 2 antibody; NF-kappa-B inhibitor-like protein 2 antibody; NFBIL2 antibody; NFBIL2/TONSL antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2 antibody; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 antibody; Protein IkappaBR antibody; Tonsl antibody; TONSL_HUMAN antibody; Tonsoku-like protein antibody; tonsoku-like, DNA repair protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Tonsoku-like protein (668-955AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.

Gene References into Functions

By specifically regulating RAD51 activity at uncoupled replication forks, MMS22L-TONSL stabilizes perturbed replication forks by promoting replication fork reversal and stimulating their homologous recombination-mediated restart in vivo. PMID: 27797818
new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL-MMS22L homologous recombination complex PMID: 27338793
Common NFKBIL2 polymorphisms are associated with susceptibility to invasive pneumococcal infection. PMID: 21171993
Results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks. PMID: 21113133
These results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks. PMID: 21055983
MMS22L and TONSL are required for the maintenance of genome stability. PMID: 21055984
This study identifies MMS22L-NFKBIL2 as components of the replication stress control pathway. PMID: 21055985

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Subcellular Location

Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.

Protein Families

Tonsoku family

Tissue Specificity

Expressed in heart, skeletal muscle and tracheal epithelial cells.

Database Links

HGNC: 7801

OMIM: 604546

KEGG: hsa:4796

STRING: 9606.ENSP00000386239

UniGene: Hs.675285

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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